Welcome to the Controlled in vitro Microenvironments Laboratory at the Izmir Institute of Technology
Our long term goal is to better understand the cell biology of breast cancer metastasis. It is known that changes in three important biological processes namely, cell adhesion, matrix degradation and cell motility play crucial roles in metastasis. To achieve our goal, we focus on
1-Design and fabrication of micro- and nano-devices that mimic the cellular microenvironment
2-Microenvironmental control and biophysics of cell adhesion, invasion and migration in breast cancer
We use tools of nanotechnology such as UV lithography and electron beam lithography to create Controlled in vitro Microenvironments (CIVM). CIVM allow us to investigate the breast cancer microenvironment with precise control of spatial (2D and 3D; nanometers to centimeters) and temporal (seconds to days) parameters. Finally, we use various fluorescence microscopy techniques to examine the cell biology in CIVM.
In the future, we intend to use CIVM we develop for diagnostic purposes.
TÜBİTAK 1003 (Priority Fields) Project titled -Drug Delivery via Targeted Microbubbles as Ultrasound Contrast Agent and Their Use in Cancer Treatment via Controlled Local Drug Release- has been accepted. Pesen Lab will carry out CIVM experiments for a period of three years with principal investigator Dr. Sevgi Kilic Ozdemir from the Department of Chemical Engineering at IYTE and in collaboration with Dr. Mustafa Secil from the Department of Radiology, School of Medicine at Dokuz Eylul University.
Pesen Lab members, Murat Sağlam and Emre Tarım have been awarded a 2014 TEKNOGİRİŞİM (Technological Business Venture) grant by the Science, Industry and Technology Ministry of Turkey. The project will be funded with 100,000 TL for one year.
Undergraduate research project submitted by Pesen Lab undergraduates Tuğçe Oruç, Berrin Özdil and Sevgi Önal is accepted by TÜBİTAK.
Yaz stajları için, lisans öğrencilerinden genel not ortalaması 3.00/4.00 ve üzeri olanlara öncelik verilecektir. İlgilenen öğrenciler özgeçmişleri ve not dökümleri ile başvurabilirler.
Curiosity + Creativity + Courage + Collaboration = Science